Quantifying the unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects

James Zou, Gregory Valiant, Paul Valiant, Konrad Karczewski, Siu On Chan, Kaitlin Samocha, Monkol Lek, Exome Aggregation Consortium, Shamil Sunyaev, Mark Daly, Daniel G MacArthur Microsoft Research, One Memorial Drive, Cambridge MA, USA Computer Science Department, Stanford University, Palo Alto CA, USA Computer Science Department, Brown University, Providence RI, USA Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston MA, USA Broad Institute or MIT and Harvard, Cambridge MA, USA Computer Science and Engineering, Chinese University of Hong Kong, Hong Kong, China. Exome Aggregation Consortium (ExAC), Cambridge MA, USA Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston MA, USA Department of Medicine, Harvard Medical School, Boston MA, USA